Key result
Six months of low-dose perindopril and indapamide therapy significantly improved coronary vasodilator reserve from 2.05 at baseline to 5.49 (p=0.0498) in patients with essential hypertension.
Why the study?
Does low-dose perindopril and indapamide improve coronary vasodilator reserve in newly-diagnosed hypertensive patients?
Population
6 newly-diagnosed, never-treated patients with uncomplicated moderate essential hypertension without…
Design
Case_series, PET data analyses for MBF quantifications were performed at the…
Follow-up
6 months
Authors
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Hypothesis-generating for coronary microvascular effects of low-dose perindopril-indapamide; larger trials needed before practice change.
Does low-dose perindopril and indapamide improve coronary vasodilator reserve in newly-diagnosed hypertensive patients?
Absolute Event Rate: 5.49% vs 2.05%
p-value: p=0.0498
Six months of low-dose perindopril and indapamide therapy significantly improved impaired coronary vasodilator reserve and normalized blood pressure in newly diagnosed hypertensive patients.
Mourad et al. (2003) conducted a letter in Essential hypertension (n=6). perindopril and indapamide vs. Baseline was evaluated on Coronary vasodilator reserve (CVR) (p=0.0498). Six months of low-dose perindopril and indapamide therapy significantly improved coronary vasodilator reserve from 2.05 at baseline to 5.49 (p=0.0498) in patients with essential hypertension.
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