Why the study?
Does perindopril prevent cardiac hypertrophy in low-renin hypertensive rats?
Population
Rats with low-renin hypertension induced by partial renal ablation and 1% sodium chloride supplementation
Comparison
Perindopril 3 mg/kg per day or 1 mg/kg per day… vs 1% sodium chloride alone or tap water
Design
Preclinical, randomly divided into four groups
Authors
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Perindopril may limit cardiac hypertrophy independently of BP in low-renin rat models; leaves open translation to human LVH prevention.
Does perindopril prevent cardiac hypertrophy in low-renin hypertensive rats?
Perindopril prevents left ventricular hypertrophy in a low-renin hypertensive rat model independent of blood pressure reduction or renin-angiotensin system suppression.
Nakamura et al. (1993) studied this question.
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