Why the study?
Does perindopril prevent cardiac hypertrophy via blood pressure reduction or cardiac ACE inhibition in a rat model of myocardial infarction?
Population
Rat model of myocardial infarction
Comparison
Perindopril or 1% saline as drinking fluid plus… vs Vehicle or 1% saline as drinking fluid
Design
Preclinical
Follow-up
6 weeks
Authors
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BP reduction, not cardiac ACE inhibition, drives perindopril's anti-hypertrophic effect in this rat MI model; leaves open clinical relevance and human translation.
Does perindopril prevent cardiac hypertrophy via blood pressure reduction or cardiac ACE inhibition in a rat model of myocardial infarction?
The beneficial effects of ACE inhibition on cardiac hypertrophy post-MI in rats are primarily driven by blood pressure reduction rather than direct cardiac ACE inhibition.
Yoshida et al. (1998) studied this question.
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