Why the study?
Does perindopril improve left ventricular performance and normalize sympathetic activity in a rat model of developing cardiac failure?
Population
Rats with left coronary artery ligation for 15 days to induce myocardial infarction and cardiac failure
Comparison
Perindopril 2 mg/kg body weight orally vs Nontreated infarct group
Design
Preclinical
Follow-up
15 days
Authors
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Perindopril preserves output and sympathetic tone in rat MI; leaves open translation to human heart failure.
Does perindopril improve left ventricular performance and normalize sympathetic activity in a rat model of developing cardiac failure?
In a rat model of myocardial infarction, perindopril improved left ventricular performance, reduced hypertrophy, and normalized sympathetic activity.
Ribuot et al. (1990) studied this question.
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