Key result
Perindopril therapy for one month in rats with chronic left ventricular failure returned cardiac weights to normal and significantly reduced right ventricular DHPG/NA ratios.
Why the study?
Does perindopril therapy reduce cardiac sympathetic activity and cardiomegaly in a rat model of chronic left ventricular failure?
Does perindopril therapy reduce cardiac sympathetic activity and cardiomegaly in a rat model of chronic left ventricular failure?
ACE inhibition with perindopril reduces elevated cardiac sympathetic activity and leads to regression of cardiomegaly in a rat model of chronic heart failure.
Answers are grounded in this paper and cite their sources.
Suggests perindopril may modulate sympathetic activity in experimental HF; leaves open clinical translation pending human trials.
Left ventricular myocardial infarction was induced in female Wistar rats by ligation of the left anterior descending coronary artery. 2. One month following operation, rats with infarcts developed marked cardiomegaly compared to sham operated rats, indicating the presence of chronic left ventricular failure. 3. The ratio of the noradrenaline metabolite 3,4-dihydroxyphenylethylene glycol (DHPG) to noradrenaline (NA) was elevated in the right ventricle of rats with heart failure one month following infarction, suggesting a chronic increase in cardiac sympathetic activity. 4. Perindopril therapy for one month commenced 4 weeks after infarction returned cardiac weights to normal and significantly reduced right ventricular DHPG/NA ratios. 5. The results suggest that ACE inhibition with perindopril reduces elevated levels of cardiac sympathetic activity in rats with chronic left ventricular failure and leads to regression of cardiomegaly.
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Howes et al. (1989) studied chronic left ventricular failure. Perindopril vs. Sham operated rats / untreated rats with heart failure was evaluated on Cardiac weights and right ventricular DHPG/NA ratios. Perindopril therapy for one month in rats with chronic left ventricular failure returned cardiac weights to normal and significantly reduced right ventricular DHPG/NA ratios.
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