Why the study?
Does perindopril prevent myocardial hypertrophy and electrophysiological alterations in rats following left coronary artery ligation?
Population
Rats in which ligation of the left coronary artery had produced hypertrophy of the non-infarcted myocardium
Comparison
Perindopril 2 mg/kg body weight given orally vs Untreated rats with left coronary artery ligation
Design
Preclinical
Follow-up
1 month
Authors
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Supports post-MI remodeling hypothesis in rats; leaves open human translation and clinical adoption.
Does perindopril prevent myocardial hypertrophy and electrophysiological alterations in rats following left coronary artery ligation?
ACE inhibition with perindopril prevents compensatory myocardial hypertrophy and associated action potential prolongation in the non-infarcted myocardium of rats post-myocardial infarction.
Thollon et al. (1989) studied this question.
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