Key result
In spontaneously hypertensive rats, low-dose indapamide plus perindopril significantly lowered systolic and diastolic blood pressures (P<0.001) and reversed cardiac and larger vessel hypertrophy.
Why the study?
Does a low dose combination of indapamide and perindopril improve cardiovascular structure and function in spontaneously hypertensive rats?
Population
Male spontaneously hypertensive rats (SHR), 10-12 weeks old
Comparison
Fixed low dose combination of indapamide +… vs Vehicle
Design
Preclinical
Follow-up
8 weeks
Authors
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Does not support clinical use; hypothesis-generating for cardiac remodeling in hypertension models.
Does a low dose combination of indapamide and perindopril improve cardiovascular structure and function in spontaneously hypertensive rats?
p-value: p=<0.001
Low-dose indapamide plus perindopril reduces blood pressure and reverses cardiac and larger vessel hypertrophy in spontaneously hypertensive rats.
Ibrahim et al. (1999) studied Genetic hypertension. Indapamide + perindopril vs. Vehicle was evaluated on Systolic and diastolic blood pressures, and cardiovascular structure (p=<0.001). In spontaneously hypertensive rats, low-dose indapamide plus perindopril significantly lowered systolic and diastolic blood pressures (P<0.001) and reversed cardiac and larger vessel hypertrophy.
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