Why the study?
Does acute administration of fixed combination perindopril-indapamide improve endothelial function in patients with essential hypertension?
Population
13 patients with essential hypertension and 13 matched controls (total n=26)
Comparison
Acute administration of fixed combination… vs Placebo
Design
RCT, randomized, crossover, double-blind
Follow-up
acute administration
Authors
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Acute perindopril-indapamide supports endothelial assessment in hypertension management; extends RCT evidence for fixed ACEI-diuretic effects on FMD.
Does acute administration of fixed combination perindopril-indapamide improve endothelial function in patients with essential hypertension?
Acute administration of a low-dose fixed combination of perindopril and indapamide improves conduit artery endothelial function in patients with essential hypertension.
Joannidès et al. (2008) studied this question.
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