Key result
Indapamide decreased blood pressure and left ventricular hypertrophy but did not affect total myocardial fibrosis, whereas its combination with captopril or red wine polyphenols decreased all parameters in hypertensive rats.
Why the study?
Does indapamide alone or in combination with captopril or Provinols reduce myocardial hypertrophy and fibrosis in L-NAME-induced hypertensive rats?
Does indapamide alone or in combination with captopril or Provinols reduce myocardial hypertrophy and fibrosis in L-NAME-induced hypertensive rats?
Combining antihypertensive therapy with antioxidant treatment effectively prevents myocardial remodeling and fibrosis in a hypertensive rat model.
The aim of this study was to analyze the effect of indapamide and its combination with ACE inhibitor (captopril) and antioxidant (Provinols™) on both myocardial hypertrophy and fibrosis. Wistar rats were treated with L-NAME (40 mg/kg/day, L); L-NAME plus indapamide (1 mg/kg/day), or captopril (10 mg/kg/day), or Provinols™ (40 mg/kg/day), or combination of indapamide with captopril, and indapamide with Provinols™ for 7 weeks. Blood pressure (BP), LV hypertrophy and fibrosis were determined. The content of collagens type I and III was evaluated morphometrically after picrosirius red staining. L-NAME treatment led to increased BP, LV hypertrophy, total fibrosis and relative content of collagens without the change in collagen type I/III ratio. Indapamide and captopril decreased BP, LV hypertrophy and the collagen ratio without affecting total fibrosis, while Provinols™ reduced BP, the collagen ratio and fibrosis without affecting LV hypertrophy. The combinations decreased all the parameters. Decrease of LV hypertrophy was achieved by drugs with the best reducing effect on BP, fibrosis reduction was reached by the antioxidant treatment with only partial effect on BP. Thus, the combination of antihypertensive and antioxidant treatment may represent a powerful tool in preventing myocardial remodeling induced by hypertension.
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Hlavačková et al. (2011) studied L-NAME-induced hypertension (n=48). Indapamide vs. L-NAME (40 mg/kg/day) was evaluated on Relative left ventricular weight (LVW/BW in mg/g) (p=<0.05). Indapamide decreased blood pressure and left ventricular hypertrophy but did not affect total myocardial fibrosis, whereas its combination with captopril or red wine polyphenols decreased all parameters in hypertensive rats.
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