What question did this study set out to answer?

To evaluate the long-term effects of oral trandolapril treatment on survival, hemodynamics, and cardiac and vascular histomorphological remodeling in rats with heart failure following myocardial infarction.

July 1, 1992Journal of Cardiovascular Pharmacology

Long-Term Treatment with Trandolapril Opposes Cardiac Remodeling and Prolongs Survival After Myocardial Infarction in Rats

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Why the study?

Does 1-year oral treatment with trandolapril improve survival and cardiac remodeling in rats developing congestive heart failure after myocardial infarction?

Population

Rats developing congestive heart failure after myocardial infarction (MI)

Comparison

Trandolapril oral treatment for 1 year vs Control MI rats and sham-operated rats

Design

Preclinical

Follow-up

1 year

Authors

CRChristine RicherInserm PMPaul MulderUniversité Paris-Sud PFPaul FornesUniversité Paris-Sud

Discussion

Member takes

Implication

Supports long-term ACEI in experimental post-MI HF; leaves open human translation and optimal duration.

Key Points

To evaluate the long-term effects of oral trandolapril treatment on survival, hemodynamics, and cardiac and vascular histomorphological remodeling in rats with heart failure following myocardial infarction.
Monitored rats with myocardial infarction administered oral trandolapril over a 1-year period alongside untreated infarction controls and sham-operated groups.
Evaluated survival rates, life expectancy, blood pressure, diuresis, and histomorphological parameters of the heart and aorta at regular intervals.
Trandolapril significantly extended survival rate and overall duration, prolonging life expectancy by approximately 6 months in post-infarction rats.
Treatment produced immediate, persistent hemodynamic benefits, including significantly decreased arterial blood pressure and elevated diuresis.
Starting at 3 to 6 months, treatment significantly suppressed cardiac remodeling by decreasing heart weight, limiting left ventricular hypertrophy, and reducing myocardial and aortic fibrosis.

Structured PICO

Does 1-year oral treatment with trandolapril improve survival and cardiac remodeling in rats developing congestive heart failure after myocardial infarction?

Population

Rats developing congestive heart failure after myocardial infarction (MI)

Intervention

Trandolapril oral treatment for 1 year

Comparator

Control MI rats and sham-operated rats (with and without trandolapril)

Outcome

Survival rate and durationhard clinical

In a rat model of post-MI heart failure, long-term trandolapril improves survival and attenuates adverse cardiac remodeling through early hemodynamic and later antihypertrophic/antifibrotic effects.

Cite This Study

Richer et al. (1992) studied this question.

synapsesocial.com/papers/6a7f40fde052db6f994a5b83 https://doi.org/10.1097/00005344-199207000-00019

Topics

Heart failure HFrEF treatment

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Long-Term Treatment with Trandolapril Opposes Cardiac Remodeling and Prolongs Survival After Myocardial Infarction in Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Long-Term Treatment with Trandolapril Opposes Cardiac Remodeling and Prolongs Survival After Myocardial Infarction in Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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