A Clinical Trial of the Angiotensin-Converting–Enzyme Inhibitor Trandolapril in Patients with Left Ventricular Dysfunction after Myocardial Infarction
Why the study?
Does trandolapril reduce mortality and severe heart failure in patients with reduced left ventricular function after myocardial infarction?
Population
Patients with reduced left ventricular function soon after myocardial infarction
Design
RCT, randomized
Follow-up
long-term
Authors
Discussion
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Member takes
Implication
Supports long-term ACE inhibitor use post-MI with LV dysfunction; confirms mortality and severe HF prevention in RCT.
Structured PICO
Does trandolapril reduce mortality and severe heart failure in patients with reduced left ventricular function after myocardial infarction?
P
Population
Patients with reduced left ventricular function soon after myocardial infarction
I
Intervention
Trandolapril (long-term treatment)
O
Outcome
Overall mortality, mortality from cardiovascular causes, sudden death, and the development of severe heart failurehard clinical
Long-term treatment with trandolapril significantly reduces mortality and the development of severe heart failure in patients with left ventricular dysfunction after myocardial infarction.
Cite This Study
Køber et al. (1995) studied this question.