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December 1, 2003European Heart Journal

The angiotensin converting enzyme inhibitor trandolapril has neutral effect on exercise tolerance or functional class in patients with myocardial infarction and reduced left ventricular systolic function

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Why the study?

Does trandolapril improve exercise tolerance time and NYHA classification in patients with reduced left ventricular systolic dysfunction after acute myocardial infarction?

Population

1749 consecutive Danish patients with reduced left ventricular systolic dysfunction after acute myocardial…

Comparison

Trandolapril vs Control arm (not explicitly detailed in abstract)

Design

RCT, randomized

Follow-up

up to 4 years

Authors

JAJawdat AbdullaAmager Hospital

Discussion

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Overview

Trandolapril yields no functional gains in post-MI LVSD; challenges expectations for symptomatic ACEI benefit beyond diuretic sparing.

Structured PICO

Does trandolapril improve exercise tolerance time and NYHA classification in patients with reduced left ventricular systolic dysfunction after acute myocardial infarction?

P
Population
1749 consecutive Danish patients with reduced left ventricular systolic dysfunction (LVSD) after acute myocardial infarction (AMI). A prospective sub-study included 254 patients.
I
Intervention
Trandolapril
C
Comparator
Control arm (not explicitly detailed in abstract)
O
Outcome
Exercise tolerance time (ETT) at 1, 3, and 12 months, and New York Heart Association (NYHA) classification over 4 yearspatient reported

Trandolapril does not significantly improve exercise tolerance or NYHA functional class in patients with LVSD post-AMI, though it has a mild diuretic-sparing effect.

Cite This Study

Jawdat Abdulla (2003) studied this question.

synapsesocial.com/papers/6a70530ce5469ee92be110e2https://doi.org/10.1016/j.ehj.2003.09.004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Failure of an ACE inhibitor to improve exercise tolerance. A randomized study of trandolapril1998 · 11 citations
  2. 2A Clinical Trial of the Angiotensin-Converting–Enzyme Inhibitor Trandolapril in Patients with Left Ventricular Dysfunction after Myocardial Infarction1995 · 1,781 citations
  3. 3Absence of effect on exercise capacity of 12-weeks treatment with ramipril in patients with moderate congestive heart failure1994 · 31 citations
  4. 4Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure1991 · 8,072 citations
  5. 5What is the ideal study design for evaluation of treatment for heart failure?: Insights from trials assessing the effect of ACE inhibitors on exercise capacity1996 · 94 citations