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December 1, 1998European Heart JournalOpen Access

Failure of an ACE inhibitor to improve exercise tolerance. A randomized study of trandolapril

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Why the study?

Does trandolapril improve exercise tolerance in patients with moderate heart failure?

Population

292 patients with moderate (New York Heart Association Grades II and III) heart failure

Comparison

Trandolapril in addition to diuretics for 16 weeks vs Placebo in addition to diuretics for 16 weeks

Design

RCT, randomized, double-blind

Follow-up

16 weeks

Authors

JHJ R HamptonWestern University

Discussion

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Overview

Trandolapril adds no exercise tolerance benefit in moderate HF; confirms neutral effect atop diuretics in this RCT.

Structured PICO

Does trandolapril improve exercise tolerance in patients with moderate heart failure?

P
Population
292 patients with moderate (New York Heart Association Grades II and III) heart failure
I
Intervention
Trandolapril in addition to diuretics for 16 weeks
C
Comparator
Placebo in addition to diuretics for 16 weeks
O
Outcome
Exercise tolerance on a treadmill assessed at baseline and after 4, 8, 12 and 16 weeks of treatment (using modified Bruce and modified Naughton protocols)surrogate

Trandolapril added to diuretics does not significantly improve exercise tolerance in patients with moderate heart failure over a 16-week period.

Cite This Study

J R Hampton (1998) studied this question.

synapsesocial.com/papers/6a72a515febe604dd70ab3e4https://doi.org/10.1053/euhj.1998.1241

Topics

HFrEF treatmentHeart failure
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The angiotensin converting enzyme inhibitor trandolapril has neutral effect on exercise tolerance or functional class in patients with myocardial infarction and reduced left ventricular systolic function2003 · 14 citations
  2. 2Exercise testing in hypertensive patients taking different angiotensin-converting enzyme inhibitors2003 · 3 citations
  3. 3Trandolapril in left ventricular dysfunction after myocardial infarction: Focus in the TRACE study2003 · 1 citations
  4. 4Trandolapril Does Not Improve Insulin Sensitivity in Patients with Hypertension and Type 2 Diabetes: A Double-Blind, Placebo-Controlled Crossover Trial<sup>1</sup>2000 · 35 citations
  5. 5Long-Term Trandolapril Treatment Is Associated With Reduced Aortic Stiffness2007 · 106 citations