Why the study?
Do captopril and enalapril have differential effects on tissue ACE activities and renal function in rats with experimental heart failure?
Population
39 rats
Comparison
Captopril or enalapril administered for 1 week… vs Vehicle treatment
Design
Preclinical
Follow-up
47 days
Authors
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ACEI tissue selectivity in rat HF is hypothesis-generating; leaves open clinical relevance and requires human validation.
Do captopril and enalapril have differential effects on tissue ACE activities and renal function in rats with experimental heart failure?
Chronic treatment with captopril and enalapril elicits differential effects on tissue ACE activities and renal angiotensinogen regulation in experimental heart failure.
Hirsch et al. (1992) studied this question.
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