Why the study?
Do angiotensin II converting enzyme inhibitors improve hemodynamics and clinical status in patients with severe congestive heart failure refractory to digitalis and diuretics?
Do angiotensin II converting enzyme inhibitors improve hemodynamics and clinical status in patients with severe congestive heart failure refractory to digitalis and diuretics?
Chronic ACE inhibition with captopril or enalapril provides significant hemodynamic and clinical improvement in patients with severe, refractory heart failure.
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May support acute hemodynamic effects of enalapril in refractory HF; leaves open durability of benefit and clinical outcomes.
Turini et al. (1983) studied this question.
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