Key result
Enalapril and candesartan significantly attenuated the central pressor response to i.c.v. hypertonic saline in SHR compared to vehicle (12 and 11 vs 29 mmHg, respectively).
Why the study?
Does chronic antihypertensive treatment reduce the central pressor response in spontaneously hypertensive rats?
Does chronic antihypertensive treatment reduce the central pressor response in spontaneously hypertensive rats?
In spontaneously hypertensive rats, chronic treatment with enalapril and candesartan, but not losartan or hydralazine/hydrochlorothiazide, significantly attenuates the central pressor response to hypertonic saline.
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Suggests central RAS modulation in SHR; leaves open translation to human hypertension therapy.
Lin et al. (2001) studied Hypertension (Spontaneously Hypertensive Rats) (n=53). Enalapril, losartan, candesartan, or hydralazine+hydrochlorothiazide vs. Vehicle was evaluated on Pressor response to i.c.v. hypertonic saline (0.5 M). Enalapril and candesartan significantly attenuated the central pressor response to i.c.v. hypertonic saline in SHR compared to vehicle (12 and 11 vs 29 mmHg, respectively).
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