Why the study?
Does S 9490 and its active form S 9780 inhibit ACE and reduce blood pressure in animal models?
Population
Preclinical models including guinea pigs, rabbits, rats, cats, and dogs
Comparison
S 9490 and its diacid form S 9780 vs MK 421 and MK 422, and baseline/control conditions
Design
Preclinical
Follow-up
Up to 24 hours
Authors
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Supports preclinical ACE inhibitor development; leaves open translation to human cardiovascular therapy.
Does S 9490 and its active form S 9780 inhibit ACE and reduce blood pressure in animal models?
S 9490 and its active form S 9780 are potent, long-acting ACE inhibitors in various animal models, with effects appearing to exceed those of MK 421 and MK 422.
Laubie et al. (1984) studied this question.
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