Key result
In the two-kidney one-clip Goldblatt rabbit, renin inhibitors EMD 58265 and U 71038 decreased blood pressure approximately 10 mmHg more than the ACE inhibitor enalaprilat.
Why the study?
Does intravenous renin inhibition reduce blood pressure more effectively than ACE inhibition in two-kidney one-clip Goldblatt rabbits?
Population
Anaesthetized two-kidney one-clip Goldblatt rabbits
Comparison
Intravenous administration of human renin… vs Intravenous administration of the ACE inhibitor…
Design
Preclinical
Authors
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May support renin inhibition preference in high-renin states; hypothesis-generating without human data.
Does intravenous renin inhibition reduce blood pressure more effectively than ACE inhibition in two-kidney one-clip Goldblatt rabbits?
Effect estimate: approx 10 mmHg greater decrease
Renin inhibition is more effective than ACE inhibition in lowering blood pressure in a rabbit model with high circulating AngII levels.
Ben G. Zimmerman (2000) studied Hypertension (two-kidney one-clip Goldblatt rabbit model). Renin inhibitors (EMD 58265 and U 71038) vs. Enalaprilat (2-4 mg/kg and 10 mg/kg i.v.) was evaluated on mean blood pressure (approx 10 mmHg greater decrease). In the two-kidney one-clip Goldblatt rabbit, renin inhibitors EMD 58265 and U 71038 decreased blood pressure approximately 10 mmHg more than the ACE inhibitor enalaprilat.
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