Key result
Renin inhibitor U-71038 matches captopril in reducing peripheral resistance without altering cardiac output or GFR.
Why the study?
Does renin inhibition with U-71038 produce similar systemic and renal haemodynamic effects compared to ACE inhibition with captopril in conscious sodium-depleted cynomolgus monkeys?
Population
Conscious sodium-depleted cynomolgus monkeys
Comparison
Renin inhibitor U-71038 vs Angiotensin converting enzyme inhibitor captopril
Design
Preclinical
Authors
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Similar hemodynamic effects of renin vs ACE inhibition in sodium-depleted primates; leaves open translation to human hypertension.
Does renin inhibition with U-71038 produce similar systemic and renal haemodynamic effects compared to ACE inhibition with captopril in conscious sodium-depleted cynomolgus monkeys?
Renin inhibition and ACE inhibition produce fundamentally similar cardiovascular and renal hemodynamic effects in sodium-depleted non-human primates, likely via decreased formation of angiotensin II.
Pals et al. (1989) studied Sodium depletion. U-71038 vs. Captopril was evaluated on Systemic and renal haemodynamic effects (cardiac output, total peripheral resistance, heart rate, glomerular filtration rate). The renin inhibitor U-71038 and the ACE inhibitor captopril produced similar reductions in total peripheral resistance without altering cardiac output, heart rate, or glomerular filtration rate.
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