January 1, 1991Clinical and Experimental Hypertension

Additive Combination Studies of Captopril and Ditekiren, a Renin Inhibitor, in Nonhuman Primates

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Why the study?

Does the combination of captopril and ditekiren reduce blood pressure additively in conscious cynomolgus monkeys?

Population

Conscious sodium-depleted and sodium replete cynomolgus monkeys

Design

Preclinical

Authors

DPDonald T. PalsW.E. Upjohn Institute for Employment Research GDG L DeGraafPfizer (United States)SCSally J. CouchW.E. Upjohn Institute for Employment Research

Discussion

Member takes

Implication

Supports further study of ACEI-renin inhibitor combinations; leaves open applicability to human hypertension management.

Structured PICO

Does the combination of captopril and ditekiren reduce blood pressure additively in conscious cynomolgus monkeys?

Population

Conscious sodium-depleted and sodium replete cynomolgus monkeys

Intervention

Combination of captopril (ACE inhibitor) and ditekiren (renin inhibitor)

Outcome

Hypotensive response (blood pressure)surrogate

The combination of captopril and ditekiren produces additive or over-additive hypotensive effects in cynomolgus monkeys, likely via decreased angiotensin II formation.

Cite This Study

Pals et al. (1991) studied this question.

synapsesocial.com/papers/6a7584adb47a809cc2e71f30 https://doi.org/10.3109/10641969109045061

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Additive Combination Studies of Captopril and Ditekiren, a Renin Inhibitor, in Nonhuman Primates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Additive Combination Studies of Captopril and Ditekiren, a Renin Inhibitor, in Nonhuman Primates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider