Why the study?
Does a single oral dose of combined losartan and captopril reduce blood pressure and alter renin/aldosterone levels more than either drug alone in sodium-depleted normotensive men?
Population
12 normotensive male volunteers maintained in mild sodium depletion
Comparison
Single oral dose of combined losartan 50 mg and… vs Single oral dose of losartan 50 mg alone…
Design
RCT, randomized, four-way, crossover, double-blind
Follow-up
24 hours
Authors
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ACEI/ARB combination yields greater acute BP reduction than monotherapy; confirms additive effects and extends dual blockade rationale in sodium-depleted states.
Does a single oral dose of combined losartan and captopril reduce blood pressure and alter renin/aldosterone levels more than either drug alone in sodium-depleted normotensive men?
Combined administration of an ACE inhibitor and an Ang II antagonist has additive effects on blood pressure reduction and plasma renin rise in sodium-depleted normotensive subjects.
Azizi et al. (1995) studied this question.
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