Why the study?
Does the combination of captopril and losartan reduce blood pressure more than higher doses of either drug alone in spontaneous hypertensive rats?
Population
Spontaneous hypertensive rats (SHR)
Comparison
Captopril 10 mg/kg administered with losartan 10… vs Captopril 20 mg/kg or losartan 20 mg/kg alone
Design
Preclinical
Follow-up
1 week
Authors
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Does not support dual ACEI/ARB use in patients; leaves open additive BP effects beyond high-dose monotherapy in hypertensive models.
Does the combination of captopril and losartan reduce blood pressure more than higher doses of either drug alone in spontaneous hypertensive rats?
Combining an ACE inhibitor and an AT1-receptor blocker is more effective at lowering blood pressure than monotherapy at higher doses in a hypertensive rat model.
Morgan et al. (2002) studied this question.
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