Key result
Adding losartan to maximally tolerated ACE inhibition in heart failure patients safely reduced systolic blood pressure from 122 to 107 mm Hg (p<0.001).
Why the study?
Does adding losartan to maximally tolerated ACE inhibitors safely reduce blood pressure in patients with symptomatic congestive heart failure?
Observational (n=43)
Does adding losartan to maximally tolerated ACE inhibitors safely reduce blood pressure in patients with symptomatic congestive heart failure?
Absolute Event Rate: 107% vs 122%
p-value: p=<0.001
Adding losartan to maximal ACE inhibitor therapy safely reduces blood pressure and provides further vasodilation in patients with symptomatic heart failure.
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May support cautious dual RAS blockade for BP control in HF; leaves open outcome benefits and safety in RCTs.
Hamroff et al. (1997) conducted an observational in Congestive heart failure (n=43). Losartan vs. Baseline (ACE inhibitor alone) was evaluated on Systolic blood pressure (p=<0.001). Adding losartan to maximally tolerated ACE inhibition in heart failure patients safely reduced systolic blood pressure from 122 to 107 mm Hg (p<0.001).