Addition of Angiotensin II Receptor Blockade to Maximal Angiotensin-Converting Enzyme Inhibition Improves Exercise Capacity in Patients With Severe Congestive Heart Failure
Why the study?
Does the addition of losartan to maximal ACE inhibition improve exercise capacity in patients with severe congestive heart failure?
Population
33 patients with severe congestive heart failure despite treatment with maximally recommended or tolerated…
Comparison
Losartan 50 mg/d for 6 months in addition to… vs Matching placebo for 6 months in addition to…
Design
RCT, 1:1, double-blind
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Supports adding losartan to maximal ACE inhibition to improve exercise capacity in severe HF; extends ARB evidence in ACEI-treated patients.
Structured PICO
Does the addition of losartan to maximal ACE inhibition improve exercise capacity in patients with severe congestive heart failure?
P
Population
33 patients with severe congestive heart failure (CHF) despite treatment with maximally recommended or tolerated doses of ACE inhibitors
I
Intervention
Losartan 50 mg/d for 6 months in addition to standard therapy
C
Comparator
Matching placebo for 6 months in addition to standard therapy
O
Outcome
Peak aerobic capacity (V(O2)) during symptom-limited treadmill exercise at 3 and 6 monthssurrogate
The addition of losartan to maximal ACE inhibition significantly improves peak exercise capacity and NYHA functional class in patients with severe congestive heart failure.
Cite This Study
Hamroff et al. (1999) studied this question.