Key result
Exercise training completely restored aerobic capacity and energy transfer enzymes, while combined treatment with losartan yielded the best improvement in aerobic capacity and ventricular pressure.
Why the study?
Does exercise training and/or losartan improve aerobic capacity, cardiac function, and energy metabolism in a rat model of post-myocardial infarction heart failure?
Population
Female Sprague-Dawley rats with heart failure induced by myocardial infarction via coronary artery ligation
Comparison
Losartan, exercise training, or combined treatment vs Untreated heart failure
Design
Preclinical
Follow-up
12 weeks after surgery
Authors
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Hypothesis-generating in rat post-MI HF; leaves open translation of combined exercise-losartan benefits to patients.
Does exercise training and/or losartan improve aerobic capacity, cardiac function, and energy metabolism in a rat model of post-myocardial infarction heart failure?
In a rat model of post-myocardial infarction heart failure, exercise training and losartan act via complementary mechanisms, with exercise restoring cardiac energy metabolism and losartan unloading the heart.
Kemi et al. (2007) studied Heart failure after myocardial infarction. Exercise training and/or losartan vs. Single interventions vs combined was evaluated on Maximal oxygen uptake, cardiac function and energy metabolism. Exercise training completely restored aerobic capacity and energy transfer enzymes, while combined treatment with losartan yielded the best improvement in aerobic capacity and ventricular pressure.
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