Why the study?
Does aerobic interval training improve myocardial energy metabolism and cardiac function in rats with chronic heart failure?
Does aerobic interval training improve myocardial energy metabolism and cardiac function in rats with chronic heart failure?
Aerobic interval training improves metabolic remodeling and cardiac function in a rat model of post-MI heart failure, potentially through the AMPK/PPARα pathway.
AIT may restore myocardial energy metabolism in post-MI CHF rats; leaves open translation to human heart failure.
OBJECTIVES: Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. MATERIALS AND METHODS: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were randomly divided into sham operation group (Sham group), CHF model group, and CHF exercise group (Exercise-CHF group). RESULTS: 0.05) in the CHF-model group. Importantly, AIT reversed these alterations induced by post-MI. CONCLUSION: Findings of this study demonstrated that AIT could improve the metabolic remodeling and enhance cardiac function, which may be associated with the activation of AMPK/ peroxisome proliferator activated receptor α (PPARα) and its downstream signaling pathway.
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Wang et al. (2018) studied this question.
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