Key result
Aerobic interval training in post-infarction rats reduced the decline in complex I-dependent mitochondrial respiration (17% vs 37% decrease; P<0.05) and preserved LV fractional shortening.
Why the study?
Does aerobic interval training improve LV fractional shortening and mitochondrial function in post-infarction failing rat hearts?
Population
Adult female Sprague-Dawley rats, 4 weeks after left coronary artery ligation (MI)
Comparison
8 weeks of aerobic interval treadmill running vs Sedentary group and sham-operated animals
Design
Preclinical, randomized
Follow-up
8 weeks
Authors
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Hypothesis-generating for aerobic training in post-MI HF; human trials required before any clinical consideration.
RCT
randomized
Does aerobic interval training improve LV fractional shortening and mitochondrial function in post-infarction failing rat hearts?
Absolute Event Rate: 17% vs 37%
p-value: p=< 0.05
Aerobic interval training attenuates left ventricular contractile deterioration and mitochondrial dysfunction in a rat model of post-infarction heart failure.
Kraljević et al. (2013) conducted an RCT in Myocardial infarction. Aerobic interval training vs. Sedentary was evaluated on Decrease in complex I-dependent respiration compared with sham-operated animals (p=< 0.05). Aerobic interval training in post-infarction rats reduced the decline in complex I-dependent mitochondrial respiration (17% vs 37% decrease; P<0.05) and preserved LV fractional shortening.
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