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April 1, 2002ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction

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Key result

Aerobic endurance training in rats with myocardial infarction reduced left and right ventricular weights by 15% and 23%, and myocyte length and width by 12% and 20% versus sedentary controls.

Why the study?

Does aerobic endurance training improve cardiomyocyte hypertrophy, contractility, and Ca2+ handling in a rat model of myocardial infarction?

Population

36 adult female Sprague-Dawley rats, 4 weeks after ligation of the left coronary artery or sham operation

Comparison

Aerobic endurance training on a treadmill vs Sedentary controls (sham-operated and infarcted)

Design

Preclinical

Follow-up

8 weeks

Authors

UWUlrik Wisløff

Discussion

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Overview

Caution against clinical adoption post-MI; leaves open translation of hypertrophy attenuation from this rat model.

Key Points

  • The aim is to determine how aerobic exercise affects cardiac function and cellular mechanisms after myocardial infarction in rats.
  • Adult female Sprague-Dawley rats underwent treadmill exercise for 1.5 hours/day, 5 days/week for 8 weeks.
  • Training was initiated 4 weeks post-ligation of the left coronary artery.
  • Control groups consisted of sedentary rats with sham or infarction procedures.
  • V(O(2max)) in exercise groups was 65% above sedentary controls after 6 weeks.
  • Trained rats showed reduced ventricular weights and myocyte dimensions compared to sedentary infarction group.
  • Aerobic training significantly increased SERCA-2 and NCX levels, improving Ca2+ handling and contractility.

Structured PICO

Does aerobic endurance training improve cardiomyocyte hypertrophy, contractility, and Ca2+ handling in a rat model of myocardial infarction?

P
Population
36 adult female Sprague-Dawley rats, 4 weeks after ligation of the left coronary artery (n=24) or sham operation (n=12)
I
Intervention
Aerobic endurance training on a treadmill (1.5 h/day, 5 days/week for 8 weeks, alternating intervals of 8 min at 85-90% VO2max and 2 min at 50-60%)
C
Comparator
Sedentary controls (sham-operated and infarcted)
O
Outcome
Myocardial mass, myocyte dimensions, contractile function, Ca2+ handling, and myofilament responsiveness to Ca2+ in cardiomyocytessurrogate

Aerobic endurance training attenuates ventricular and cellular hypertrophy and restores contractile function and Ca2+ handling in a rat model of myocardial infarction.

Cite This Study

Ulrik Wisløff (2002) studied Myocardial infarction (n=36). Aerobic endurance training vs. Sedentary controls was evaluated on Myocardial mass, myocyte dimensions, contractile function, Ca2+ handling, and myofilament responsiveness to Ca2+. Aerobic endurance training in rats with myocardial infarction reduced left and right ventricular weights by 15% and 23%, and myocyte length and width by 12% and 20% versus sedentary controls.

synapsesocial.com/papers/6a0e9359a7f61df77cc86355https://doi.org/10.1016/s0008-6363(01)00565-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SERCA2a and mitochondrial cytochrome oxidase expression are increased in hearts of exercise-trained old rats1996 · 69 citations
  2. 2Molecular Basis of Human Cardiac Troponin T Isoforms Expressed in the Developing, Adult, and Failing Heart1995 · 245 citations
  3. 3Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.1978 · 7,474 citations
  4. 4Sprint training restores normal contractility in postinfarction rat myocytes2000 · 43 citations
  5. 5Sprint training attenuates myocyte hypertrophy and improves Ca2+homeostasis in postinfarction myocytes1998 · 40 citations