Key result
Progressive treadmill exercise increased Ca2+ sensitivity of tension and aMLC1 expression more in subendocardial than subepicardial myocytes in female rats.
Why the study?
Does progressive treadmill exercise alter Ca2+ sensitivity of tension and contractile protein isoform expression differently across the ventricular wall in female Sprague-Dawley rats?
Population
Female Sprague-Dawley rats
Comparison
11 weeks of progressive treadmill exercise vs Sedentary control
Design
Preclinical
Follow-up
11 weeks
Authors
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May reflect transmural heterogeneity in exercise-induced myocyte changes in female rats; leaves open translation to human cardiac physiology or outcomes.
Does progressive treadmill exercise alter Ca2+ sensitivity of tension and contractile protein isoform expression differently across the ventricular wall in female Sprague-Dawley rats?
Endurance exercise training enhances myocyte Ca2+ sensitivity and aMLC1 expression more prominently in the subendocardial region than the subepicardial region in rats.
Diffee et al. (2003) studied this question. Progressive treadmill exercise vs. Sedentary control was evaluated on Ca2+ sensitivity of tension and atrial myosin light chain 1 (aMLC1) expression in subendocardial vs subepicardial myocytes. Progressive treadmill exercise increased Ca2+ sensitivity of tension and aMLC1 expression more in subendocardial than subepicardial myocytes in female rats.