Key result
Chronic exercise training elicited an approximately 5% increase in resting myocyte length (126.7 vs 121.0 microns; P < 0.05) and altered shortening dynamics in isolated rat cardiac myocytes.
Why the study?
Does chronic exercise training alter contractility and morphology in isolated rat cardiac myocytes?
Population
Left ventricular cardiac myocytes isolated from the hearts of rats
Comparison
Chronic exercise training vs Sedentary control
Design
Preclinical
Authors
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Hypothesis-generating in rat myocytes; human studies required before any clinical implications.
Does chronic exercise training alter contractility and morphology in isolated rat cardiac myocytes?
Absolute Event Rate: 126.7% vs 121%
p-value: p=< 0.05
Chronic exercise training induces longitudinal myocyte growth and alters contractile function at the single myocyte level, likely by influencing Ca2+ handling.
Moore et al. (1993) studied Healthy (animal model). Chronic exercise training vs. Sedentary control was evaluated on Resting myocyte length (p=< 0.05). Chronic exercise training elicited an approximately 5% increase in resting myocyte length (126.7 vs 121.0 microns; P < 0.05) and altered shortening dynamics in isolated rat cardiac myocytes.
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