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October 27, 2010Brazilian Journal of Medical and Biological ResearchOpen Access

Exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes obtained from spontaneously hypertensive rats

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Why the study?

Does exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes in spontaneously hypertensive rats?

Population

4-month-old spontaneously hypertensive rats (SHR)

Comparison

Treadmill-running trained for 8 weeks with or… vs Sedentary for 8 weeks or sedentary for 12 weeks

Design

Preclinical, randomly divided

Follow-up

8 to 12 weeks

Authors

MCMiguel Araujo Carneiro‐JúniorUniversidade Federal de ViçosaMPMaria do Carmo Gouveia PelúzioUniversidade Federal de ViçosaCSC.H.O. SilvaUniversidade Federal de Viçosa

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Implication

Hypothesis-generating in hypertensive rat myocytes; human studies needed before any clinical translation.

Structured PICO

Does exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes in spontaneously hypertensive rats?

P
Population
4-month-old spontaneously hypertensive rats (SHR)
I
Intervention
Treadmill-running trained for 8 weeks (16 m/min, 60 min/day, 5 days/week) with or without 4 weeks of detraining
C
Comparator
Sedentary for 8 weeks (SED-8) or sedentary for 12 weeks (SED-12)
O
Outcome
Morphological and mechanical properties of left ventricular myocytes (resting cell length, width, cell shortening, maximum velocity of shortening and relengthening)surrogate

Exercise training induces eccentric hypertrophy and improves contractile function in left ventricular myocytes of hypertensive rats, but functional improvements are lost after detraining.

Cite This Study

Carneiro‐Júnior et al. (2010) studied this question.

synapsesocial.com/papers/6a87d70970098fa105bb5bbbhttps://doi.org/10.1590/s0100-879x2010007500117
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic exercise alters contractility and morphology of isolated rat cardiac myocytes1993 · 99 citations
  2. 2Endurance Training in the Spontaneously Hypertensive Rat2009 · 99 citations
  3. 3Transmural changes in size, contractile and electrical properties of SHR left ventricular myocytes during compensated hypertrophy2004 · 100 citations
  4. 4Contractile properties of ventricular myocytes isolated from spontaneously hypertensive rat1992 · 37 citations
  5. 5Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats1997 · 226 citations