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February 17, 2009HypertensionOpen Access

Endurance Training in the Spontaneously Hypertensive Rat

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Why the study?

Does endurance training improve cardiac hypertrophy and performance in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and normotensive Wistar rats

Comparison

Endurance training vs Sedentary SHRs and normotensive Wistar rats

Design

Preclinical

Follow-up

60 days

Authors

CGCarolina D. GarciarenaRoyal College of Surgeons in IrelandOPOscar Andrés PinillaCentro de Investigaciones CardiovascularesMNMariela B. NollyConsejo Nacional de Investigaciones Científicas y Técnicas

Discussion

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Implication

May support exercise in hypertensive hypertrophy models; hypothesis-generating and requires human trials before clinical consideration.

Structured PICO

Does endurance training improve cardiac hypertrophy and performance in spontaneously hypertensive rats?

P
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar rats
I
Intervention
Endurance training (swimming 90 min/d for 5 days a week for 60 days)
C
Comparator
Sedentary SHRs (SHR-Cs) and normotensive Wistar rats
O
Outcome
Cardiac hypertrophy assessed by left ventricular weight/tibial length, myocyte cross-sectional area, collagen volume fraction, capillary density, and echocardiographic midventricular shorteningsurrogate

Endurance training in spontaneously hypertensive rats converts pathological cardiac hypertrophy into physiological hypertrophy, improving cardiac performance and reducing myocardial fibrosis.

Cite This Study

Garciarena et al. (2009) studied this question.

synapsesocial.com/papers/6a83bc4bf4298de60b3c2822https://doi.org/10.1161/hypertensionaha.108.126805

Topics

Hypertension management
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Also Consider

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