Key result
Moderate levels of regular aerobic exercise corrected systolic elastance in spontaneously hypertensive rats (P<0.05) and attenuated systolic dysfunction.
Why the study?
Does moderate aerobic exercise improve systolic function and alter apoptotic signaling in hypertensive myocardium in rats?
Does moderate aerobic exercise improve systolic function and alter apoptotic signaling in hypertensive myocardium in rats?
p-value: p=<0.05
Moderate aerobic exercise attenuates systolic dysfunction early in the compensatory phase of hypertension-induced hypertrophy, independent of lowering caspase 3 activity.
Exercise training attenuates early systolic dysfunction in hypertensive rat hearts; leaves open clinical translation and apoptosis effects in humans.
The general purpose of this study was to test the effect of exercise training on the left ventricular (LV) pressure-volume relationship (LV/PV) and apoptotic signaling markers in normotensive and hypertensive hearts. Four-month-old female normotensive Wistar-Kyoto rats (WKY; n = 37) and spontaneously hypertensive rats (SHR; n = 38) were assigned to a sedentary (WKY-SED, n = 21; SHR-SED, n = 19) or treadmill-trained (WKY-TRD, n = 16; SHR-TRD, n = 19) group (∼60% Vo(2 peak), 60 min/day, 5 days/wk, 12 wk). Ex vivo LV/PV were established in isovolumic Langendorff-perfused hearts, and LV levels of Akt, phosphorylated Akt (Akt(Pi)), Bad, phosphorylated Bad (Bad(Pi)) c-IAP, x-IAP, calcineurin, and caspases 3, 8, and 9 were measured. Heart-to-body weight ratio was increased in SHR vs. WKY (P < 0.05), concomitant with increased calcineurin mRNA (P < 0.05). There was a rightward shift in the LV/PV (P < 0.05) and a reduction in systolic elastance (E(s)) in SHR vs. WKY. Exercise training corrected E(s) in SHR (P < 0.05) but had no effect on the LV/PV in WKY. Caspase 3 was increased in SHR-SED relative to WKY-SED, while Bad(Pi,) c-IAP, and x-IAP were significantly lower in SHR relative to WKY (P < 0.05). Exercise training increased Bad(Pi) in both WKY and SHR but did not alter caspase 9 activity in either group. While caspase 3 activity was increased with training in WKY (P < 0.05), it was unchanged with training in SHR. We conclude that moderate levels of regular aerobic exercise attenuate systolic dysfunction early in the compensatory phase of hypertrophy, and that a differential phenotypical response to moderate-intensity exercise exists between WKY and SHR.
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Libonati et al. (2011) studied Hypertension (n=75). Exercise training (treadmill) vs. Sedentary was evaluated on Left ventricular (LV) pressure-volume relationship (LV/PV) and apoptotic signaling markers (p=<0.05). Moderate levels of regular aerobic exercise corrected systolic elastance in spontaneously hypertensive rats (P<0.05) and attenuated systolic dysfunction.
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