Key result
Aerobic exercise enhances cardiomyocyte calcium handling and transient decay in hypertensive rat models.
Why the study?
Regulation of intracellular calcium in cardiomyocytes is altered by hypertension, and the effects of aerobic exercise on this regulation and miR-214 expression in hypertensive rats were investigated.
Does aerobic exercise training improve intracellular calcium transients and contractility in cardiomyocytes of spontaneously hypertensive rats?
Does aerobic exercise training improve intracellular calcium transients and contractility in cardiomyocytes of spontaneously hypertensive rats?
Aerobic exercise training improves intracellular calcium handling in cardiomyocytes of hypertensive rats.
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Does not support clinical changes; leaves open translation of exercise effects on cardiomyocyte calcium handling from hypertensive rat models.
Rodrigues et al. (2018) studied Hypertension. Aerobic exercise training vs. Sedentary was evaluated on Contractility, intracellular calcium transients, and miR-214 expression. Aerobic exercise training increased intracellular Ca2+ amplitude and reduced the time to 50% decay of Ca2+ transients in spontaneously hypertensive rats.
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