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August 27, 2014Brazilian Journal of Medical and Biological ResearchOpen Access

Effect of exercise training on Ca2+ release units of left ventricular myocytes of spontaneously hypertensive rats

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Key result

Endurance exercise training partially reverses hypertensive effects on calcium release units, reducing spark frequency ~18%.

  • n=28

Why the study?

Hypertension causes defects in calcium release unit function in cardiomyocytes, and it is unclear whether endurance exercise training can attenuate these effects in left ventricular myocytes.

Does endurance exercise training improve calcium release unit components and Ca2+ sparks in left ventricular myocytes of spontaneously hypertensive rats?

Comparison

Endurance exercise training vs sedentary control

Design

Preclinical experimental study with 4 groups

Follow-up

8 weeks

Authors

MCMiguel Araujo Carneiro‐JúniorUniversidade Federal de ViçosaJQJudson Fonseca Quintão-JúniorUniversidade Federal de ViçosaLDLucas Rios DrummondUniversidade do Estado de Minas Gerais

Discussion

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Implication

Exercise may attenuate Ca2+ defects in hypertensive rat myocytes; leaves open translation to human hypertension.

Structured PICO

Does endurance exercise training improve calcium release unit components and Ca2+ sparks in left ventricular myocytes of spontaneously hypertensive rats?

P
Population
28 male Wistar and spontaneously hypertensive rats (4 months of age) underwent an 8-week low-intensity treadmill running protocol.
I
Intervention
Low-intensity treadmill running protocol (5 days/week, 1 h/day, 0% grade, and 50-60% of maximal running speed) for 8 weeks
C
Comparator
Sedentary control groups (implied, though abstract text contains a likely typo stating NC and HC were submitted to the running protocol)
O
Outcome
Gene expression of ryanodine receptor type 2 (RyR2) and FK506 binding protein (FKBP12.6), and Ca2+ sparks characteristics (frequency, amplitude, full width at half-maximum amplitude, total duration, time to peak, and time constant of decay)surrogate

Main Result

Absolute Event Rate: 6.26% vs 7.61%

Endurance exercise training attenuates the deleterious effects of hypertension on calcium release units and Ca2+ sparks in left ventricular myocytes in a rat model.

Cite This Study

Carneiro‐Júnior et al. (2014) studied Hypertension (n=28). Endurance exercise training vs. Sedentary control was evaluated on Frequency of Ca2+ sparks (per 100 µm/s). Endurance exercise training partially reversed the deleterious effects of hypertension on calcium release units, reducing Ca2+ spark frequency from 7.61 to 6.26 per 100 µm/s.

synapsesocial.com/papers/6aaf65ad4104dfdc38cea065https://doi.org/10.1590/1414-431x20144063
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic exercise partially restores the transmural heterogeneity of action potential duration in left ventricular myocytes of spontaneous hypertensive rats2012 · 14 citations
  2. 2Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats2011 · 26 citations
  3. 3Exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes obtained from spontaneously hypertensive rats2010 · 20 citations
  4. 4Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation2009 · 104 citations
  5. 5Dyssynchronous Ca 2+ Sparks in Myocytes From Infarcted Hearts2000 · 170 citations