Chronic exercise partially restores the transmural heterogeneity of action potential duration in left ventricular myocytes of spontaneous hypertensive rats
Key result
An 8-week treadmill-running programme partially restored the transmural heterogeneity of action potential duration in left ventricular myocytes of spontaneously hypertensive rats.
Why the study?
Does chronic exercise improve the electrophysiological properties of left ventricular myocytes in spontaneously hypertensive rats?
Population
Male spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar male rats
Comparison
Chronic exercise for 8 weeks vs Sedentary spontaneously hypertensive rats and…
Design
Preclinical
Follow-up
8 weeks
Authors
Discussion
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Implication
Should not yet change practice; hypothesis-generating for exercise effects on human hypertensive electrophysiology.
Structured PICO
Does chronic exercise improve the electrophysiological properties of left ventricular myocytes in spontaneously hypertensive rats?
P
Population
Male spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar male rats subjected to an 8-week treadmill-running programme.
I
Intervention
Chronic exercise (treadmill-running programme) for 8 weeks
C
Comparator
Sedentary spontaneously hypertensive rats (SED-SHR) and sedentary normotensive Wistar rats
O
Outcome
Action potential duration (APD) and transient outward potassium current (I(to)) in subepicardial (EPI) and subendocardial (ENDO) LV myocytessurrogate
An 8-week treadmill running program partially restores transmural action potential heterogeneity in spontaneously hypertensive rats, independent of blood pressure reduction.
Cite This Study
Roman‐Campos et al. (2012) studied Hypertension. Chronic exercise (treadmill-running programme) vs. Sedentary (SED-SHR) was evaluated on Transmural heterogeneity of action potential duration (APD) and transient outward potassium current (I(to)). An 8-week treadmill-running programme partially restored the transmural heterogeneity of action potential duration in left ventricular myocytes of spontaneously hypertensive rats.