Key result
Progressive treadmill exercise prolongs action potential and increases sarcolemmal Ca2+ binding sites by ~63%.
Why the study?
The mechanisms by which myocardium adapts to exercise training remain to be further investigated.
Comparison
Progressively trained for 12 weeks vs sedentary control
Design
Randomized controlled preclinical study
Follow-up
12 weeks
Authors
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Exercise training augments papillary muscle tension in rats; leaves open translation to human myocardial adaptation or clinical benefit.
RCT (n=60)
randomly divided
Absolute Event Rate: 30% vs 20.2%
Exercise training enhances cardiac performance by increasing calcium availability to the contractile element through sarcolemmal adaptations.
Tibbits et al. (1981) conducted an RCT in Healthy (n=60). Progressive treadmill exercise training vs. Sedentary control was evaluated on Action potential duration at 0 mV. Progressive treadmill exercise training significantly prolonged the action potential at 0 mV (30.0 vs 20.2 ms) and increased predicted sarcolemmal Ca2+ binding sites by 63%.
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