Key result
Treadmill training lowers myocardial Na+-Ca2+ exchanger apparent Km by ~57% versus sedentary controls.
Why the study?
Does exercise training modify the Na+-Ca2+ exchanger in cardiac sarcolemma in rats?
RCT (n=72)
Randomly divided
Does exercise training modify the Na+-Ca2+ exchanger in cardiac sarcolemma in rats?
Absolute Event Rate: 15.7% vs 36.1%
Exercise training increases the affinity of the cardiac Na+-Ca2+ exchanger for Ca2+, which may play a role in the adaptation of the heart to exercise by enhancing myocardial contractility.
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Hypothesis-generating for exercise effects on rat myocardial Ca2+ handling; leaves open translation to human cardiac function or outcomes.
Tibbits et al. (1989) reported an RCT. Treadmill-training paradigm vs. Sedentary control was evaluated on Apparent Km of the myocardial Na+-Ca2+ exchanger for Ca2+ (microM). An 11-week treadmill-training paradigm significantly lowered the apparent Km of the myocardial Na+-Ca2+ exchanger for Ca2+ compared to sedentary controls (15.7 vs 36.1 microM).
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