Key result
11 weeks of progressive treadmill exercise in rats significantly increased tension output of isolated left ventricular papillary muscle (2.2 vs. 1.5 g.mm-2; P<0.025).
Why the study?
Does progressive treadmill exercise improve myocardial contractile function in rats?
Population
Rats (n=40 total; 20 trained, 20 control)
Comparison
11 weeks of progressive treadmill exercise vs Control rats
Design
Preclinical
Follow-up
11 weeks
Authors
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Hypothesis-generating in rats; leaves open whether endurance training enhances human myocardial contractility.
Does progressive treadmill exercise improve myocardial contractile function in rats?
Absolute Event Rate: 2.2% vs 1.5%
p-value: p=<0.025
Endurance training in rats increases myocardial tension output per unit area, likely due to increased calcium availability, without changing myofibril ATPase activity.
Tibbits et al. (1978) studied Healthy (animal model) (n=40). Progressive treadmill exercise vs. Control was evaluated on Tension output of isolated left ventricular papillary muscle (g.mm-2) (p=<0.025). 11 weeks of progressive treadmill exercise in rats significantly increased tension output of isolated left ventricular papillary muscle (2.2 vs. 1.5 g.mm-2; P<0.025).
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