Why the study?
Does exercise training combined with losartan improve post-infarct ventricular remodelling and cardiac function in rats?
Population
Sprague-Dawley rats with myocardial infarction induced by ligation of the left descending coronary artery
Comparison
Losartan treatment and exercise training… vs Sedentary MI (MISed) group
Design
Preclinical
Follow-up
8 weeks
Authors
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Does not alter post-MI care; leaves open whether exercise plus losartan synergistically improves remodeling in humans.
Does exercise training combined with losartan improve post-infarct ventricular remodelling and cardiac function in rats?
In a rat model of myocardial infarction, combining exercise training with losartan attenuated myocardial fibrosis and preserved cardiac function better than either intervention alone.
Xu et al. (2008) studied this question.
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