Key result
Combination therapy with lisinopril and losartan was more effective than individual treatments in reducing mortality and ventricular remodeling in rats 3 months after myocardial infarction.
Why the study?
Does combination therapy with lisinopril and losartan improve ventricular remodeling and survival in rats after myocardial infarction compared to either drug alone or no treatment?
Does combination therapy with lisinopril and losartan improve ventricular remodeling and survival in rats after myocardial infarction compared to either drug alone or no treatment?
In a rat model of myocardial infarction, combining an ACE inhibitor and an AT1 receptor antagonist was more effective than either agent alone in preventing ventricular remodeling and improving survival.
No takes yet. Share an insight, caveat, or question.
Animal data on post-MI remodeling warrant no practice change; leaves open whether combination therapy benefits humans.
Zornoff et al. (2000) studied Myocardial Infarction. Lisinopril plus losartan vs. Untreated, lisinopril alone, and losartan alone was evaluated on Mortality, ventricular remodeling, and ventricular function. Combination therapy with lisinopril and losartan was more effective than individual treatments in reducing mortality and ventricular remodeling in rats 3 months after myocardial infarction.
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