Why the study?
Does losartan or enalapril improve left ventricular remodeling in mice post-myocardial infarction?
Does losartan or enalapril improve left ventricular remodeling in mice post-myocardial infarction?
In a mouse model of myocardial infarction, AT1 receptor antagonism and ACE inhibition demonstrate equivalent inhibitory effects on myocardial hypertrophy and fibrosis.
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Equivalent effects on hypertrophy and fibrosis in post-MI mice leave open translation to human remodeling therapies.
Patten et al. (2003) studied this question.
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