Key result
Irbesartan treatment in post-MI rats effectively decreased ventricular hypertrophy, improved the time constant of isovolumic relaxation (tau), and normalized ANP expression.
Why the study?
Does irbesartan improve diastolic function and inhibit ventricular hypertrophy in post-myocardial infarction male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats undergoing coronary ligation (post-myocardial infarction) or sham operation
Comparison
Irbesartan (selective AT1-receptor antagonist) vs No treatment
Design
Preclinical
Follow-up
6 weeks
Authors
Loading...
Supports irbesartan for post-MI remodeling in rats; leaves open translation to human diastolic function trials.
Does irbesartan improve diastolic function and inhibit ventricular hypertrophy in post-myocardial infarction male Sprague-Dawley rats?
In a rat model of post-MI remodeling, AT1-receptor antagonism with irbesartan reduced ventricular hypertrophy and improved diastolic function independent of ventricular loading conditions.
Ambrose et al. (1999) studied Post-myocardial infarction ventricular remodeling. Irbesartan vs. No treatment was evaluated on Cardiac hypertrophy, diastolic function, and SERCA/PLB gene expression. Irbesartan treatment in post-MI rats effectively decreased ventricular hypertrophy, improved the time constant of isovolumic relaxation (tau), and normalized ANP expression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: