Why the study?
Does irbesartan improve systemic haemodynamics and cardiac remodelling compared to enalapril in post-myocardial-infarcted rats?
Population
Post-myocardial-infarcted (MI) Sprague-Dawley rats
Comparison
Irbesartan 50 mg/kg/day orally for 4 weeks vs Enalapril 10 mg/kg/day orally for 4 weeks, and…
Design
Preclinical
Follow-up
4 weeks
Authors
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Does not support changing post-MI therapy; leaves open whether AT1 blockade limits LV dilatation more than ACE inhibition in patients.
Does irbesartan improve systemic haemodynamics and cardiac remodelling compared to enalapril in post-myocardial-infarcted rats?
In a rat model of post-myocardial infarction, AT1-receptor blockade with irbesartan provided better cardioprotective benefits, specifically limiting LV dilatation, compared to ACE inhibition with enalapril.
Lacour et al. (2004) studied this question.
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