Why the study?
Does irbesartan reduce myocardial infarct size and apoptosis in a rat model of myocardial ischemia/reperfusion injury?
Does irbesartan reduce myocardial infarct size and apoptosis in a rat model of myocardial ischemia/reperfusion injury?
Pretreatment with the AT1 receptor antagonist irbesartan significantly reduces myocardial infarct size and attenuates cardiomyocyte apoptosis in a rat model of ischemia/reperfusion injury.
Hypothesis-generating for AT1 blockade in cardioprotection; leaves open translation to human ischemia/reperfusion injury.
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Nam et al. (2001) studied this question.
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