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Experimental animal models and cultured human coronary artery endothelial cells subjected to…
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May support AT1 blockade in ischemia-reperfusion injury; leaves open clinical translation from preclinical models.
Blockade of myocardial AT1 receptors using antisense oligodeoxynucleotides or losartan attenuates ischemia-reperfusion-induced cardiac dysfunction and apoptosis in preclinical models.
Yang et al. (1998) studied this question.
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