Population
Rats subjected to myocardial infarction via ligation of the left anterior descending coronary artery
Comparison
Myocardial infarction vs Sham-operated controls
Design
Preclinical
Follow-up
4 and 20 weeks
Key result
Myocardial infarction in rats led to a transitory reduction in left ventricular AT2 receptor expression to 8% and 13% of sham values in viable and scar tissue at 4 weeks, normalizing by 20 weeks.
Authors
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Caution against clinical extrapolation from rats; leaves open timing of AT2 modulation in post-MI remodeling.
There is a selective, transitory downregulation of left ventricular AT2 receptor expression during the intermediate phase of post-MI ventricular remodelling in rats, which may enhance AT1 receptor-mediated compensatory growth.
Lax et al. (2004) studied Myocardial infarction. Myocardial infarction (LAD ligation) vs. Sham-operated group was evaluated on Relative cardiac AT1 and AT2 receptor expression levels. Myocardial infarction in rats led to a transitory reduction in left ventricular AT2 receptor expression to 8% and 13% of sham values in viable and scar tissue at 4 weeks, normalizing by 20 weeks.
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