What is the clinical evidence from this study?

Study design: Other. Population: Myocardial infarction. Intervention: Moderate cardiac-selective overexpression of AT2R (via rAAV9-CBA-AT2R) vs. Control. Primary outcome: Cardiac functions (fractional shortening, rate of change of left ventricular pressure, left ventricular end-diastolic pressure).

October 4, 2011Experimental PhysiologyOpen Access

Moderate cardiac‐selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury

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Key result

Moderate cardiac-selective overexpression of AT2R attenuated MI-induced impairments in cardiac function and ventricular wall thinning in a rat model of myocardial infarction.

Why the study?

Does moderate cardiac-selective overexpression of AT2R protect cardiac function from ischaemic injury in a rat model of myocardial infarction?

Population

Rat neonatal cardiac myocytes and Sprague-Dawley rats subjected to myocardial infarction induced by coronary…

Comparison

Moderate cardiac-selective overexpression of… vs Control rats subjected to myocardial infarction…

Design

Preclinical

Follow-up

4 weeks after coronary artery ligation

Authors

YQYanfei QiThe University of Sydney HLHongwei LiBaogang Group (China)VSVinayak ShenoyPenn State Milton S. Hershey Medical Center

Discussion

Member takes

Implication

AT2R modulation merits further preclinical testing in MI; hypothesis-generating and should not yet inform clinical practice.

Structured PICO

Does moderate cardiac-selective overexpression of AT2R protect cardiac function from ischaemic injury in a rat model of myocardial infarction?

Population

Sprague-Dawley rats subjected to myocardial infarction induced by coronary artery ligation.

Intervention

Moderate cardiac-selective overexpression of angiotensin II type 2 receptor (AT2R) via rAAV9-CBA-AT2R (4 × 10^10 vg) injected into the left ventricle (prevention study) or peri-infarcted myocardium (post-treatment study).

Comparator

Control rats subjected to myocardial infarction without AT2R overexpression.

Outcome

Cardiac function assessed by echocardiography and haemodynamic measurements (fractional shortening, rate of change of left ventricular pressure, left ventricular end-diastolic pressure, ventricular hypertrophy) at 4 weeks post-MI.surrogate

Moderate cardiac-selective overexpression of AT2R protects heart function and attenuates adverse remodeling following myocardial infarction in a rat model.

Cite This Study

Qi et al. (2011) studied Myocardial infarction. Moderate cardiac-selective overexpression of AT2R (via rAAV9-CBA-AT2R) vs. Control was evaluated on Cardiac functions (fractional shortening, rate of change of left ventricular pressure, left ventricular end-diastolic pressure). Moderate cardiac-selective overexpression of AT2R attenuated MI-induced impairments in cardiac function and ventricular wall thinning in a rat model of myocardial infarction.

synapsesocial.com/papers/6a7b6ace2eb3c7e469f45105 https://doi.org/10.1113/expphysiol.2011.060673

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Moderate cardiac‐selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Moderate cardiac‐selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider