Why the study?
Does cardiac overexpression of the angiotensin II type 2 receptor improve left ventricular remodeling and dysfunction post-myocardial infarction in mice?
Population
Transgenic mice with different levels of angiotensin II type 2 receptor gene overexpression in the heart and…
Comparison
AT2R overexpression and treatment with AT2R… vs Wild-type littermates, sham MI, and MI plus…
Design
Preclinical
Follow-up
8 weeks
Authors
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Animal data on AT2R overexpression post-MI should not inform practice; leaves open dose-dependent mechanisms for translational research.
Does cardiac overexpression of the angiotensin II type 2 receptor improve left ventricular remodeling and dysfunction post-myocardial infarction in mice?
Moderate cardiac overexpression of AT2R protects against post-MI remodeling and dysfunction, whereas excessive overexpression loses this protective effect, likely via regulation of Nox2 and TGF-β1 signaling.
Xu et al. (2014) studied this question.
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