Increased expression of cardiac angiotensin II type 1 (AT) receptors decreases myocardial microvessel density after experimental myocardial infarction
Population
Transgenic rats with cardioselective overexpression of the AT1 receptor and Sprague-Dawley rats as controls…
Comparison
Selective AT1 receptor blocker losartan vs Untreated rats and sham-operated controls
Design
Preclinical
Follow-up
3 weeks
Authors
Discussion
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Implication
May extend AT1 blockade benefits to post-MI angiogenesis; leaves open translation from this transgenic rat model.
Structured PICO
P
Population
Transgenic rats (TGR) with cardioselective overexpression of the AT1 receptor and Sprague-Dawley (SD) rats as controls, subjected to experimental myocardial infarction (MI)
I
Intervention
Selective AT1 receptor blocker losartan
C
Comparator
Untreated rats (SD MI and TGR MI) and sham-operated controls
O
Outcome
Microvessel density in the non-infarcted myocardium at 3 weekssurrogate
AT1 receptor blockade post-MI may improve outcomes not only by attenuating LV remodeling but also by stimulating angiogenesis, counteracting the decrease in microvessel density exacerbated by AT1 receptor overexpression.
Cite This Study
Boer et al. (2003) studied this question.